Dr. SKS Marya continues to seek to find better methods to diagnose and subsequently deal with periprosthetic joint infection (PJI) in sufferers following total joint arthroplasty. Their cutting-edge studies suggests leukocyte esterase reagent (LE) strips, common in diagnosing urinary tract infections, also can have a position in rapid analysis of PJI.The prospective study constructed on previous work performed by Best Orthopaedic Surgeon Medanta Hospital Gurgaon to increase a higher, faster manner to diagnose PJI. PJI continues to be a subject for the industry as antibiotic-resistance organisms have accelerated the superiority of post-surgical periprosthetic infections. Deep periprosthetic joint infection is presently the most common indication for revision of total knee arthroplasty and the third most frequent indication for revision of total hip arthroplasty.
The team hypothesized that more than the neutrophils themselves; it's far the enzymes they secrete that may be better markers for contamination. They examined the sensitivity and specificity of a way for detecting one of those enzymes, leukocyte esterase. Esterase is an enzyme launched by using white blood cells and is related to other types of bacterial infections, along with urinary tract infections.
They done intraoperative aspirations on 117 patients among 2007 and 2009 and tested for the presence of leukocyte esterase using an easy colorimetric strip test. Color alternate, denoting the presence and stage of enzyme, became recorded.
Of these tested, 23 had been determined to be infected and 94 were decided to be uninfected. When the use of the highest degree of infection as the edge for a positive test, the test was 86. 4 percentage sensitive for infection and 95.8 percentage specific for esterase, and while the use of smallest stage of detected contamination as threshold, the test was found to be 59.8 percent sensitive and 98.8 percentage precise, showing that checking out for leukocyte esterase in the synovial fluid is a precious addition to the diagnostic armamentarium for PJI. LE strips additionally useful resource in fast testing.
“At the same time as that is our first trail of LE strips to be used in diagnosing PJI, our findings display the test to be correct for detecting infection inside the synovial fluid. That is encouraging as we hold in our research to higher recognize, detect and treat PJI in our patients,” said Best Orthopaedic Surgeon Medanta Hospital Gurgaon.
Contact Dr. SKS Marya Medanta Hospital Gurgaon
CH Baktawar Singh Rd,
Sector 38, Medicity,
Islampur Colony, Gurugram,
Haryana 122001
Email - dr.sksmarya@jointsurgeryhospital.com
Call for Appointment - +91 9860432255